维持性血液透析患者的血清铁蛋白测定及骨髓铁储备

Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis.

作者信息

Bell J D, Kincaid W R, Morgan R G, Bunce H, Alperin J B, Sarles H E, Remmers A R

出版信息

Kidney Int. 1980 Feb;17(2):237-41. doi: 10.1038/ki.1980.27.

DOI:10.1038/ki.1980.27

Abstract

Fifty-five patients on maintenance hemodialysis underwent bone-marrow aspirations for evaluation of iron stores that were to be compared to concomitant measurements of hematocrit, red blood cell volume, serum iron concentration, total iron binding capacity, transferrin saturation, and serum ferritin concentration. In 42 patients (76.4%), the bone marrow iron stores were found to be absent or deficient. Mean hematocrit for the total group was 26.4%, and red blood cell volume measurement showed a mean value of 41.1% of predicted normal. Results also indicated that serum ferritin was the best predictor of iron storage levels, with diagnostic thresholds of 80 to 350 ng/ml derived from statistical analysis of the data. Other hematologic parameters studied had significantly less correlation with bone-marrow iron stores.

摘要

55名维持性血液透析患者接受了骨髓穿刺，以评估铁储备情况，并将其与同时测量的血细胞比容、红细胞体积、血清铁浓度、总铁结合力、转铁蛋白饱和度和血清铁蛋白浓度进行比较。在42名患者（76.4%）中，发现骨髓铁储备缺乏或不足。整个组的平均血细胞比容为26.4%，红细胞体积测量显示平均值为预测正常值的41.1%。结果还表明，血清铁蛋白是铁储存水平的最佳预测指标，通过对数据的统计分析得出诊断阈值为80至350 ng/ml。研究的其他血液学参数与骨髓铁储备的相关性明显较低。