Alexander F
Equine Vet J. 1978 Oct;10(4):229-34. doi: 10.1111/j.2042-3306.1978.tb02267.x.
The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morphine, pethidine and atropine increased faecal water.
在小马身上研究了吗啡、阿片酊、洛哌丁胺、哌替啶和阿托品对肠道转运以及粪便和尿液中水和电解质排泄的影响。颗粒标记物的通过速率被吗啡减慢，被洛哌丁胺和阿片酊先加快然后减慢，被阿托品加快。液体标记物被阿片酊减慢，被其他药物先加快然后减慢。只有洛哌丁胺减少了粪便钠排泄。这种药物还减少了粪便中的水分和重量；它似乎值得在腹泻中进行临床试验。阿片酊被吗啡、哌替啶和阿托品增加了粪便水分。
