Byun Y S, Fayos J V, Kim Y H
Laryngoscope. 1980 Jun;90(6 Pt 1):1052-60. doi: 10.1002/lary.1980.90.6.1052.
A total of 54 patients with major salivary gland tumor were treated with radiation therapy at the University of Michigan from 1955 to 1975, inclusive. Fifteen had total resection and radiation, 16 had subtotal resection and radiation, and 23 were inoperable and received radiation only. Local control rate was different between these groups, 86.7%, 75%, 21.7% respectively, as was survival rate at 5 years, 78.4%, 59.8%, 29.9%. In patients with facial nerve palsy, with combined surgery and radiation, 65.3% local control and 49.7% 5-year survival was obtained. Regional neck node metastasis was noted in 25.5% and distant metastasis in 24.1%. Local tumor control was found to be a very important factor in survival: 70.2% survival in patients with local control and 28.7% without. The authors conclude that a combined radical surgery and postoperative radiation would improve the prognosis of these patients with major salivary gland tumors.
1955年至1975年（含）期间，密歇根大学共有54例大唾液腺肿瘤患者接受了放射治疗。其中15例接受了全切除及放疗，16例接受了次全切除及放疗，23例无法手术，仅接受了放疗。这些组之间的局部控制率不同，分别为86.7%、75%、21.7%，5年生存率也不同，分别为78.4%、59.8%、29.9%。对于面神经麻痹患者，联合手术及放疗后，局部控制率为65.3%，5年生存率为49.7%。区域颈部淋巴结转移率为25.5%，远处转移率为24.1%。发现局部肿瘤控制是生存的一个非常重要的因素：局部控制的患者生存率为70.2%，未控制的患者生存率为28.7%。作者得出结论，根治性手术联合术后放疗将改善这些大唾液腺肿瘤患者的预后。
