一种制备D-α-氨基己二酸的简单方法。
A simple method for the preparation of D-alpha-aminoadipic acid.
作者信息
Chang Y F, Massey S C
出版信息
Prep Biochem. 1980;10(2):215-27. doi: 10.1080/00327488008061736.
High quantity (1 g and more) of racemically and chromatographically pure D-alpha-aminoadipic acid was prepared by selective metabolism of the L-isomer of the commercially available DL-alpha-aminoadipate by Pseudomonas putida. The overall yield of this preparation averaged 40%. The final product has [a]25D value of -25 degrees. This procedure can be useful in the synthesis of high purity D-alpha-amino-adipate, a compound shown recently to be a useful tool in the study of neurotransmission mechanism mediating synaptic excitation.
通过恶臭假单胞菌对市售DL-α-氨基己二酸的L-异构体进行选择性代谢，制备了高纯度（1克及以上）的外消旋和色谱纯D-α-氨基己二酸。该制备方法的总收率平均为40%。最终产物的比旋光度[a]25D值为-25°。该方法可用于合成高纯度的D-α-氨基己二酸，最近已证明该化合物是研究介导突触兴奋的神经传递机制的有用工具。
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