Gillette J R
Pharmacology. 1980;20(2):64-86. doi: 10.1159/000137347.
The present paper provides a theoretical base for the development of various plots that may be used in studying the sequence of events that occur when the reaction of a chemically reactive intermediate with an exogenous nucleophile is pseudo first order, and all of the other reactions by which the initial reactive metabolite decomposes are either first order or pseudo first order. Several hypothetical models that should represent most of the decomposition mechanism of chemically reactive intermediates are discussed. Problems in assessing the kinetic characteristics of diffusional barriers of the intermediates and of enzymatic reactions in the inactivation of chemically reactive intermediates are raised and the possible solution of such problems are pointed out.
本文为各种反应图的开发提供了理论基础，这些反应图可用于研究当化学反应性中间体与外源亲核试剂的反应为假一级反应，且初始反应性代谢物分解的所有其他反应均为一级或假一级反应时所发生的一系列事件。讨论了几个应能代表化学反应性中间体大部分分解机制的假设模型。提出了评估中间体扩散屏障的动力学特征以及化学反应性中间体失活过程中酶促反应的动力学特征时存在的问题，并指出了此类问题可能的解决方案。
