Ellwood D A, Mitchell M D, Anderson A B, Turnbull A C
Prostaglandins. 1980 Mar;19(3):479-88. doi: 10.1016/0090-6980(80)90082-9.
A method of tissue superfusion has been used to measure in vitro prostanoid production by the ovine cervix during late pregnancy and at parturition. In late pregnancy (105-135 days of gestation) cervical tissue produced relatively large amounts of prostaglandin E (PGE); in comparison, the production rates of prostaglandin F (PGF), 13, 14-dihydro-15-oxo-prostaglandin F (PGFM) and 6-oxo-prostaglandin F1 alpha were generally low. Thromboxane B2 (TXB2) production was minimal and often unmeasurable. There were significant increases in the production rates of PGE and 6-oxo-PGF1 alpha by cervical tissue taken immediately after delivery, when compared to late pregnancy. Mean production rates of PGE increased from 19.8 +/- 4.1 to 43.8 +/- 7.4 ng/g. dry wt./min; 6-oxo-PGF1 alpha production rates increased more than three-fold from 10.0 +/- 2.7 to 34.6 +/- 9.8 ng/g. dry wt./min (means +/- S.E.M.). There were no significant differences in the rates of production of PGF, PGFM and TXB2 by the two groups.
一种组织灌注方法已被用于测量妊娠晚期和分娩时绵羊子宫颈体外前列腺素的产生。在妊娠晚期（妊娠105 - 135天），子宫颈组织产生相对大量的前列腺素E（PGE）；相比之下，前列腺素F（PGF）、13, 14 - 二氢 - 15 - 氧代 - 前列腺素F（PGFM）和6 - 氧代 - 前列腺素F1α的产生率通常较低。血栓素B2（TXB2）的产生极少，且常常无法测量。与妊娠晚期相比，分娩后立即获取的子宫颈组织中PGE和6 - 氧代 - PGF1α的产生率显著增加。PGE的平均产生率从19.8±4.1增加到43.8±7.4 ng/g干重/分钟；6 - 氧代 - PGF1α的产生率增加了三倍多，从10.0±2.7增加到34.6±9.8 ng/g干重/分钟（均值±标准误）。两组PGF、PGFM和TXB2的产生率没有显著差异。
