McDermott W
Science. 1980 Jul 11;209(4453):240-5. doi: 10.1126/science.7384797.
The appropriate technology for control of diseases of economically underdeveloped countries happens to be mainly that applicable to groups as a whole; whereas that effective for most diseases of industrialized societies must be individually delivered. The latter area is where the pharmaceutical industry has scored its greatest triumphs, yet most of this technology does not fit the major disease problems as they now exist in the developing countries. The argument is presented that in order for the U.S. industry to do more in the developing countries, the most needed invention is not a new drug, but a new system for drug development--a new R & D system tailored specially to both the financial and the biologic needs of the problem.
控制经济欠发达国家疾病的适用技术主要适用于整个群体；而工业化社会大多数疾病的有效控制技术必须针对个体提供。制药行业在后者领域取得了最大的成功，但这些技术大多并不适用于发展中国家目前存在的主要疾病问题。有人认为，为了让美国制药行业在发展中国家发挥更大作用，最需要的发明不是一种新药，而是一种新药研发体系——一种专门根据问题的经济和生物学需求量身定制的新研发体系。
