阿片类药物和阿片肽在体外使蓝斑神经元超极化。
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.
作者信息
Pepper C M, Henderson G
出版信息
Science. 1980 Jul 18;209(4454):394-5. doi: 10.1126/science.7384811.
PMID:7384811
Abstract
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
摘要
在脑片标本中对蓝斑核神经元进行细胞内记录。阿片类药物和阿片肽可使神经元膜产生剂量依赖性、立体特异性、纳洛酮可逆的超极化。这与膜电导增加有关。
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