μ-阿片受体：来自前沿的电生理学家视角。
The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.
作者信息
Henderson Graeme
机构信息
School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
出版信息
Br J Pharmacol. 2015 Jan;172(2):260-7. doi: 10.1111/bph.12633. Epub 2014 Jul 1.
Abstract
UNLABELLED
Morphine, the prototypical opioid analgesic drug, produces its behavioural effects primarily through activation of μ-opioid receptors expressed in neurones of the central and peripheral nervous systems. This perspective provides a historical view of how, over the past 40 years, the use of electrophysiological recording techniques has helped to reveal the molecular mechanisms by which acute and chronic activation of μ-opioid receptors by morphine and other opioid drugs modify neuronal function.
LINKED ARTICLES
This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.
摘要
未标注
吗啡作为典型的阿片类镇痛药物，其行为效应主要通过激活中枢和外周神经系统神经元中表达的μ-阿片受体产生。这种观点提供了一个历史视角，展示了在过去40年里，电生理记录技术的应用如何有助于揭示吗啡和其他阿片类药物对μ-阿片受体的急性和慢性激活改变神经元功能的分子机制。
相关文章
本文是关于阿片类药物：功能选择性新途径的主题部分的一部分。要查看本节中的其他文章，请访问http://dx.doi.org/10.1111/bph.2015.172.issue-2 。
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