睾丸雌性化大鼠：雄激素非依赖性脑雄性化的自然发生模型。
The testicular feminized rat: a naturally occurring model of androgen independent brain masculinization.
作者信息
Shapiro B H, Levine D C, Adler N T
出版信息
Science. 1980 Jul 18;209(4454):418-20. doi: 10.1126/science.7384816.
PMID:7384816
Abstract
Although genotypically male (XY), the testicular feminized rat develops as an anatomic female because of an inherited deficiency in intracellular androgen receptors that prevents androgen imprinting of sexual primordia. However, the ability of testicular feminized rats to exhibit male-like sexual behavior and little feminine sexual behavior suggests that the brain can be masculinized without androgens.
摘要
尽管睾丸雌性化大鼠在基因上为雄性（XY），但由于细胞内雄激素受体的遗传性缺陷，阻止了性原基的雄激素印记，其发育为解剖学上的雌性。然而，睾丸雌性化大鼠表现出类似雄性性行为且几乎没有雌性性行为的能力表明，大脑可以在没有雄激素的情况下实现雄性化。
Zotero 插件