Kern W H, Abbott M
Surg Gynecol Obstet. 1980 Jul;151(1):73-6.
One hundred instances of lymph node metastases, including 61 per cent metastatic adenocarcinomas, 20 per cent squamous cell carcinomas and 19 per cent undifferentiated carcinomas, were examined by four pathologists on a blind review and, then again, by two with knowledge of the anatomic site and the sex of the patients. In 57 per cent, all reviews agreed with the final histologic classification, but in undifferentiated and nonkeratinizing squamous carcinomas, disagreements were common. In 59 per cent of the 77 instances of tissue confirmation, the most likely primary site was correctly indicated on the blind review, sometimes even if there was disagreement as to the histologic type. The additional information was helpful in improving the prediction of the primary site, especially for poorly differentiated carcinomas of the lung and breast. The histologic pattern of metastases can provide important information for the management of patients with metastatic carcinoma of unknown origin.
一百例淋巴结转移病例，包括61%的转移性腺癌、20%的鳞状细胞癌和19%的未分化癌，由四位病理学家进行盲法评估，然后再由两位了解解剖部位和患者性别的病理学家进行评估。在57%的病例中，所有评估结果均与最终组织学分类一致，但在未分化癌和非角化鳞状癌中，分歧很常见。在77例组织确诊病例中，59%的病例在盲法评估时正确指出了最可能的原发部位，有时即使对组织学类型存在分歧也是如此。额外的信息有助于提高对原发部位的预测，尤其是对于肺和乳腺的低分化癌。转移灶的组织学模式可为不明原发部位转移性癌患者的管理提供重要信息。
