Meyers W C, Hanks J B, Jakoi L, Quarfordt S, Jones R S
Surgery. 1980 Jul;88(1):156-61.
Biliary cholesterol secretion was studied in dogs with chronic bile fistulas, using glucagon, an inhibitor of biliary cholesterol secretion, and triparanol, an inhibitor of cholesterol synthesis. Glucagon inhibited neutral sterol secretion before and after triparanol administration. Triparanol caused a significant accumulation in bile of the cholesterol precursor desmosterol which comprised a significant portion of the neutral sterol in bile but not in blood. Glucagon inhibited both biliary desmosterol and cholesterol secretions to a similar degree. These findings suggest that biliary cholesterol is derived from newly synthesized hepatic sterol as well as from equilibrated sources. Furthermore, glucagon suppressed biliary secretion of both equilibrated as well as newly synthesized neutral sterol, suggesting that glucagon inhibits the movement of neutral sterol to or through the canalicular membrane.
利用胰高血糖素（一种胆汁胆固醇分泌抑制剂）和曲帕拉醇（一种胆固醇合成抑制剂），对患有慢性胆瘘的犬的胆汁胆固醇分泌进行了研究。在给予曲帕拉醇之前和之后，胰高血糖素均抑制中性固醇分泌。曲帕拉醇导致胆汁中胆固醇前体胆甾烯醇显著蓄积，胆甾烯醇在胆汁中的中性固醇中占很大比例，但在血液中并非如此。胰高血糖素对胆汁中胆甾烯醇和胆固醇的分泌抑制程度相似。这些发现表明，胆汁胆固醇既来源于新合成的肝脏固醇，也来源于平衡来源。此外，胰高血糖素抑制了平衡态以及新合成的中性固醇的胆汁分泌，这表明胰高血糖素抑制中性固醇向胆小管膜移动或通过胆小管膜。
