Igarashi M, Seiji M
Tohoku J Exp Med. 1980 Feb;130(2):207-8. doi: 10.1620/tjem.130.207.
A biochemical study was carried out on acidic glycosaminoglycans in the cultured skin fibroblasts obtained from a patient with epidermolysis bullosa dystrophica dominans. Acidic glycosaminoglycans were separated from fibroblasts and medium, and subjected to quantiative and qualitative analyses by cellulose acetate membrane electrophoresis, column chromatography and gel filtration. It was found that hyaluronic acid and dermatan sulfate were slightly increased in epidermolysis bullosa dystrophica dominans in comparison with the normal control.
对一名显性营养不良型大疱性表皮松解症患者的培养皮肤成纤维细胞中的酸性糖胺聚糖进行了生化研究。从成纤维细胞和培养基中分离出酸性糖胺聚糖，并通过醋酸纤维素膜电泳、柱色谱和凝胶过滤进行定量和定性分析。结果发现，与正常对照相比，显性营养不良型大疱性表皮松解症中的透明质酸和硫酸皮肤素略有增加。
