Li P L
Z Naturforsch C Biosci. 1980 Mar-Apr;35(3-4):268-72. doi: 10.1515/znc-1980-3-415.
The cytocidal action of Naja naja kaouthia venom on rabbit red blood cells and S-180 tumor cells treated with local anesthetics (tetracaine, lidocaine and procaine) were studied. The S-180 cells were more sensitive to the venom than the red blood cells which required albumin for efficient hemolysis in the 10 minute assay. All three local anesthetics at lower concentrations protected both cell types against venom hemolysis. At higher concentrations the local anesthetics enhanced the cell lysis to 100%. The effectiveness of the local anesthetics for both the inhibition and enhancement phases of cytotoxicity was tetracaine greater than lidocaine greater than procaine. This is the same order as their anesthetic effectiveness, lipid solubility and their protein binding.
研究了眼镜王蛇毒液对用局部麻醉剂（丁卡因、利多卡因和普鲁卡因）处理的兔红细胞和S-180肿瘤细胞的杀细胞作用。在10分钟的试验中，S-180细胞比红细胞对毒液更敏感，红细胞高效溶血需要白蛋白。较低浓度的所有三种局部麻醉剂都能保护两种细胞类型免受毒液溶血。在较高浓度下，局部麻醉剂可使细胞裂解率提高到100%。局部麻醉剂对细胞毒性抑制和增强阶段的有效性顺序为：丁卡因大于利多卡因大于普鲁卡因。这与它们的麻醉效力、脂溶性和蛋白质结合顺序相同。
