Nozue T
Acta Anat (Basel). 1980;106(2):246-53. doi: 10.1159/000145187.
In the lower incisors of mice injected with isoproterenol during postnatal development, cell groups or cell masses formed in the pulp showed spiral or concentric figures composed of atypical cells. Among these cells were spindle-shaped non-staining neural crest cells and spaces caused by the death of the spindle-shaped neural crest cells. In the pulp and future periodontal ligament, compact intertwining patterns of elongated spindle-shaped cells, representing non-staining neural crest cells were seen. In the periodontal ligament, the elongated spindle-shaped cells grew parallel to the ligament's long dimension. In both pulp and periodontal ligament, the cells lost 'contact inhibition', and further the histological figures resembled melanoma.
在出生后发育期间注射异丙肾上腺素的小鼠下切牙中，牙髓中形成的细胞群或细胞团呈现出由非典型细胞组成的螺旋形或同心图形。这些细胞中有纺锤形不着色的神经嵴细胞以及由纺锤形神经嵴细胞死亡导致的间隙。在牙髓和未来的牙周韧带中，可见代表不着色神经嵴细胞的细长纺锤形细胞紧密交织的模式。在牙周韧带中，细长的纺锤形细胞与韧带的长轴平行生长。在牙髓和牙周韧带中，细胞失去了“接触抑制”，并且组织学形态进一步类似于黑色素瘤。
