[血清胃泌素：放射免疫测定法的意义与局限性（作者译）]

[Serum gastrin: interests and limitations of radio-immunoassay (author's transl)].

作者信息

Rougier P, Linhart N, Bok B

出版信息

Ann Biol Clin (Paris). 1980;38(2):129-31.

Abstract

Radio-immunoassay of serum gastrin may now be carried out in all laboratories of radio-immunology. Comparison of two commercial kits A: Schwartz-Mann and B: CEA-SORIN according to criteria of specificity, sensitivity and reproducibility within and between systems, shows that they both permit the detection of pathological hypergastrinemias (Zollinger Ellison and atropic gastritis). Both kits have an identical intra-system coefficient of variation (10 p. cent and 7 p. cent for A, 5 p. cent and 8 p. cent for B) on the other hand, the inter-system coefficient of variation is better for kit B (22,4 p. cent and 37 p. cent for kit A, and 11,5 p. cent and 14,2 p. cent for kit B). The normal values for each kit are quite different: 97 + 64 pg.ml-1 for A and 51 . 23 pg.ml-1 for B preventing one from comparing estimations carried out with two different kits.

摘要

血清胃泌素的放射免疫测定现在可在所有放射免疫实验室进行。根据系统内和系统间的特异性、敏感性和可重复性标准，对两种商业试剂盒A（施瓦茨 - 曼）和B（CEA - 索林）进行比较，结果表明它们都能检测出病理性高胃泌素血症（佐林格 - 埃利森综合征和萎缩性胃炎）。两种试剂盒的系统内变异系数相同（试剂盒A为10%和7%，试剂盒B为5%和8%）。另一方面，试剂盒B的系统间变异系数更好（试剂盒A为22.4%和37%，试剂盒B为11.5%和14.2%）。每个试剂盒的正常值差异很大：试剂盒A为97±64 pg·ml⁻¹，试剂盒B为51±23 pg·ml⁻¹，这使得无法比较用两种不同试剂盒进行的测定结果。