[Rubomycin incorporation into multilayer liposomes].

Quantitative characteristics of rubomycin incorporation into sound-treated phosphatidylcholine liposomes, as well as preservation of the drug properties on storage were studied. It was found that rubomycin incorporation into the liposome lipid phase was much more efficient than that into the aqueous phase, i.e. 70 and not more than 5% of the initial amount of rubomycin respectively. The maximum incorporation of rubomycin was observed when the initial molecular ratio of rubomycin to phosphatidylcholine (lecithin) was about 1:10. With an increase in the level of cholesterol in the liposomes and the period of sound treatment, incorporation of rubomycin into the multilayer liposomes decreased. Storage of the liposome preparations for 7 days resulted in rubomycin loss by not more 5-10% of the initial incorporation level when the liposome composition was optimal.