Olson K L, Matsumura F, Boush G M
Arch Environ Contam Toxicol. 1980;9(2):247-57. doi: 10.1007/BF01055378.
Behavioral effects of toxaphene, and its toxic components, toxicant A and toxicant B, were studied by perinatally exposing juvenile rats. Toxaphene was given daily to pregnant rats (and their offspring) at 50 microgram/kg body weight via their diet. The daily dietary levels of toxicants A and B were 2.0 microgram/kg body weight. Behavioral tests were performed on the offspring. All rats fed toxaphene, as well as toxicants A and B, showed retarded maturation as judged by the swimming test during their early development. However, the treated rats eventually attained normal swimming ability. The maze retention test demonstrated significant differences between the toxicant A group and all other groups. The toxicant A animals had no difficulty in learning the test problems but were inferior to the other groups in retaining that knowledge.
通过围产期暴露幼年大鼠，研究了毒杀芬及其有毒成分毒剂A和毒剂B的行为效应。通过饮食给怀孕大鼠（及其后代）每日灌胃50微克/千克体重的毒杀芬。毒剂A和毒剂B的每日饮食剂量为2.0微克/千克体重。对后代进行行为测试。通过早期发育期间的游泳测试判断，所有喂食毒杀芬以及毒剂A和毒剂B的大鼠均表现出成熟延迟。然而，经处理的大鼠最终获得了正常的游泳能力。迷宫保持测试表明毒剂A组与所有其他组之间存在显著差异。毒剂A组的动物在学习测试问题时没有困难，但在保留该知识方面不如其他组。
