Rhind V M, Bird H A, Wright V
Ann Rheum Dis. 1980 Apr;39(2):135-7. doi: 10.1136/ard.39.2.135.
Six clinical assessments of disease activity, including a new summated change scale (SCS), have been compared in a group of 30 patients with rheumatoid arthritis seen on 8 separate occasions during their first 6 months of therapy with either D-penicillamine or hydroxychloroquine. Articular index and grip strength correlate best with erythrocyte sedimentation rate and C-reactive protein, pain score and early morning stiffness less well, and summated change score and joint circumference least well. Articular index and grip strength also correlated well with the other clinical parameters and are therefore judged to be the best clinical indices of change in treatment with these drugs.
在30例类风湿性关节炎患者中,对包括一种新的综合变化量表(SCS)在内的六种疾病活动临床评估方法进行了比较。这些患者在使用青霉胺或羟氯喹进行治疗的前6个月内,分8次接受观察。关节指数和握力与红细胞沉降率及C反应蛋白的相关性最佳,疼痛评分和晨僵的相关性稍差,综合变化评分和关节周长的相关性最差。关节指数和握力与其他临床参数也具有良好的相关性,因此被判定为这些药物治疗变化的最佳临床指标。