尿酸分泌后重吸收的孤立性缺陷。
Isolated defect in postsecretory reabsorption of uric acid.
作者信息
Sorensen L B, Levinson D J
出版信息
Ann Rheum Dis. 1980 Apr;39(2):180-3. doi: 10.1136/ard.39.2.180.
A 26-year-old woman was found to have an abnormally sensitive excretory response to a rise in plasma urate with a markedly increased ratio of uric acid to creatinine clearance (exceeding 35%). Uric acid was studied before and after administration of pyrazinamide and benzbromarone. In the presence of pyrazinamide urinary uric acid decreased markedly just as in normal subjects. The uricosuric response to benzbromarone was reduced. No other renal tubular or metabolic abnormalities were found. It appears that the abnormality is related to an isolated defect in postsecretory reabsorption of urate.
一名26岁女性被发现对血浆尿酸升高有异常敏感的排泄反应，尿酸与肌酐清除率的比值显著增加（超过35%）。在服用吡嗪酰胺和苯溴马隆前后对尿酸进行了研究。在吡嗪酰胺存在的情况下，尿尿酸明显下降，与正常受试者一样。对苯溴马隆的促尿酸排泄反应降低。未发现其他肾小管或代谢异常。看来这种异常与尿酸分泌后重吸收的孤立缺陷有关。
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