Eshaghian J, Anderson R L, Weingeist T A, Hart M N, Cancilla P A
Arch Ophthalmol. 1980 Jun;98(6):1070-3. doi: 10.1001/archopht.1980.01020031060010.
Orbicularis oculi muscle biopsies were performed in 38 patients (ten with chronic progressive external ophthalmoplegia and 28 controls) to determine whether ragged red fibers were present and, if so, whether they were specific to progressive external ophthalmoplegia. To our knowledge, the orbicularis muscle has not been previously studied in this regard. Ragged red fibers were seen in the orbicularis oculi in patients with and without ophthalmoplegia, although they were more abundant in patients with ophthalmoplegia. The limb muscles of patients with ophthalmoplegia showed ragged red fibers. Electron microscopy demonstrated that these fibers contain either abnormal or increased numbers of normal mitochondria. Thus, the presence of ragged red fibers in the orbicularis oculi muscle is not limited to patients with chronic progressive external ophthalmoplegia, and the diagnosis of this disorder with ragged red fibers should be based on a combination of clinical and laboratory findings, including those from a limb muscle biopsy.
对38例患者（10例慢性进行性眼外肌麻痹患者和28例对照者）进行眼轮匝肌活检，以确定是否存在破碎红纤维，若存在，这些纤维是否为进行性眼外肌麻痹所特有。据我们所知，此前尚未在这方面对眼轮匝肌进行研究。在有或没有眼外肌麻痹的患者的眼轮匝肌中均可见破碎红纤维，不过在有眼外肌麻痹的患者中更为丰富。眼外肌麻痹患者的肢体肌肉也显示有破碎红纤维。电子显微镜检查表明，这些纤维含有异常数量或增多的正常线粒体。因此，眼轮匝肌中存在破碎红纤维并不局限于慢性进行性眼外肌麻痹患者，基于破碎红纤维对该疾病的诊断应结合临床和实验室检查结果，包括肢体肌肉活检的结果。
