Pongratz D, Perwein J, Hübner G, Koppenwallner C, Toyka K, Birnberger K L
Klin Wochenschr. 1979 Aug 1;57(15):779-88. doi: 10.1007/BF01478036.
In skeletal muscle biopsies of nine patients with progressive external ophthalmoplegia of unknown origin "ragged red" fibers can be demonstrated. The occurrence of these abnormal fibers does not correlate with clinical muscle weakness, or additional signs of the ophthalmoplegia plus syndrome. Rarely, "ragged red" fibers are seen in other neuromuscular disorders but usually these are associated with various structural alterations. Numerous "ragged red" fibers in an otherwise normal muscle provide an essential criterion in establishing the diagnosis of the ophthalmoplegia plus syndrome.
在9例病因不明的进行性眼外肌麻痹患者的骨骼肌活检中，可发现“破碎红”纤维。这些异常纤维的出现与临床肌肉无力或眼肌麻痹加综合征的其他体征无关。在其他神经肌肉疾病中很少见到“破碎红”纤维，但通常这些与各种结构改变有关。在其他方面正常的肌肉中出现大量“破碎红”纤维是确立眼肌麻痹加综合征诊断的重要标准。
