Kawamatsu Y, Saraie T, Imamiya E, Nishikawa K, Hamuro Y
Arzneimittelforschung. 1980;30(3):454-9.
The alkanoic acids containing phenoxyphenyl moiety at omega-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl] propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKAY). The structure-activity relationship was discussed briefly.
制备了在ω位含有苯氧基苯基部分的链烷酸，并对其降血脂性能进行了测试。其中一些化合物除了具有降血脂活性外，还表现出降血糖活性。对选定的化合物3-[4-(4-氯苯氧基)苯甲酰基]丙酸(8)的进一步研究表明，它提高了肥胖和糖尿病小鼠(KKAY)脂肪组织的胰岛素敏感性。简要讨论了构效关系。
