Zucca G, Valli P, Casella C
Boll Soc Ital Biol Sper. 1980 Mar 15;56(5):435-41.
In order to define the role of Ca++ in labyrinthine receptors the endolymph in isolated canal preparations was replaced with modified solutions containing Ca-substitutes(Sr++, Ba++), Ca-antagonists(La+++, Cd++, Mg++) and Ca-chelating agents(EGTA). The response of the receptors was evaluated by recording the slow and propagated potentials from the ampullar nerve. All the tested solutions proved able to depress or cancel the mechanically evoked responses of ampullar receptors. The presence of Ca++ in the endolymph is therefore essential to grant the mechanosensitivity of the hair cells. The receptor blockade produced by Ca-withdrawal develops much earlier under continuous mechanical stimulation. This suggests that Ca++ might be bound in some structures and released during cupula deflections.
为了确定钙离子在迷路感受器中的作用，将分离的半规管制剂中的内淋巴用含有钙替代物（锶离子、钡离子）、钙拮抗剂（镧离子、镉离子、镁离子）和钙螯合剂（乙二醇双四乙酸）的改良溶液替换。通过记录壶腹神经的慢电位和扩布电位来评估感受器的反应。所有测试溶液都证明能够抑制或消除壶腹感受器的机械诱发反应。因此，内淋巴中钙离子的存在对于赋予毛细胞机械敏感性至关重要。在持续机械刺激下，因钙离子缺失导致的感受器阻滞出现得更早。这表明钙离子可能结合在某些结构中，并在嵴帽偏斜时释放。
