Cargnelli G, Finotti P, Gobbato S, Padrini R
Boll Soc Ital Biol Sper. 1980 Mar 15;56(5):474-80.
The effect of aprindine on myocardial and smooth muscle preparations activity were studied. Aprindine exerts a marked inhibition of the rate and contractility of guinea pig isolated atria and counteracts the inotropic effect induced by calcium. On the isolated guinea-pig left atrium electrically driven, apridine was found to exert negative inotropic effect both at low and high rates of stimulation, without depressing the "post-stimulation" potentiation. In spontaneously active guinea-pig taenia coli aprindine induces stimulation and regularization of the mechanical and electrical activity; on the other hand, aprindine is able to inhibit the contraction induced by acetylcholine, and this inhibition is counteracted by increasing concentration of calcium. Aprindine exerts no influence on the electrical membrane resistence of the guinea-pig taenia coli.
研究了阿普林定对心肌和平滑肌制剂活性的影响。阿普林定对豚鼠离体心房的速率和收缩力有显著抑制作用，并对抗钙诱导的变力作用。在离体豚鼠左心房电驱动实验中，发现阿普林定在低刺激频率和高刺激频率下均产生负性变力作用，且不抑制“刺激后”增强作用。在自发活动的豚鼠结肠带中，阿普林定可诱导机械和电活动的刺激和正常化；另一方面，阿普林定能够抑制乙酰胆碱诱导的收缩，且这种抑制作用可通过增加钙浓度来对抗。阿普林定对豚鼠结肠带的电膜电阻无影响。
