胎儿、新生儿和成年豚鼠肾脏中25-羟基胆钙化醇1α-羟化酶活性

25-hydroxycholecalciferol 1 alpha-hydroxylase activity in the kidney of the fetal, neonatal and adult guinea pig.

作者信息

Fenton E, Britton H G

出版信息

Biol Neonate. 1980;37(5-6):254-6. doi: 10.1159/000241284.

Abstract

Homogenates of fetal, newborn and maternal kidney and placenta have been compared with homogenates of non-pregnant adult kidney for their ability to hydroxylate 25-hydroxycholecalciferol. The activity in the fetal kidney near term is similar to that in the mother and 4--5 times that in the non-pregnant adult. These differences from the non-pregnant adult are significant (p less than 0.05 and 0.1 fetus and newborn, respectively). Even higher levels are present in some newborn 12--24 h after birth, but these values fall towards the non-pregnant level in the following 21 days. Significant hydroxylating activity is present in the near-term placenta.

摘要

已将胎儿、新生儿及母体的肾脏和胎盘匀浆与未孕成年肾脏匀浆进行比较，以研究它们使25-羟胆钙化醇羟化的能力。足月胎儿肾脏的活性与母体相似，是未孕成年肾脏的4至5倍。与未孕成年肾脏相比，这些差异具有显著性（胎儿和新生儿分别为p<0.05和p<0.1）。出生后12至24小时的一些新生儿体内水平甚至更高，但在随后的21天内这些值会降至未孕水平。足月胎盘存在显著的羟化活性。