肢端肥大症中的睡眠呼吸暂停
Sleep apnoea in acromegaly.
作者信息
Perks W H, Horrocks P M, Cooper R A, Bradbury S, Allen A, Baldock N, Prowse K, van't Hoff W
出版信息
Br Med J. 1980 Mar 29;280(6218):894-7. doi: 10.1136/bmj.280.6218.894.
Day time somnolence or excessive snoring, or both, occurred in five out of 11 patients with acromegaly. All five had episodes of sleep apnoea, and three had the sleep apnoea syndrome. Growth hormone concentrations were higher (p less than 0.025) in these patients than in the six patients without these symptoms. One patient with daytime somnolence and one asymptomatic patient had flow loop evidence of upper airways obstruction. Two of the patients with the sleep apnoea syndrome had cardiomegaly. Sleep apnoea appears to be common and clinically important in acromegaly, and it may be central, obstructive, or mixed. Polygraphic nocturnal monitoring is indicated to assess these patients properly.
11例肢端肥大症患者中有5例出现日间嗜睡或鼾声过大，或两者皆有。这5例均有睡眠呼吸暂停发作，其中3例患有睡眠呼吸暂停综合征。这些患者的生长激素浓度高于6例无这些症状的患者（p<0.025）。1例日间嗜睡患者和1例无症状患者有上气道阻塞的流量环证据。2例睡眠呼吸暂停综合征患者有心脏扩大。睡眠呼吸暂停在肢端肥大症中似乎很常见且具有临床重要性，可能是中枢性、阻塞性或混合性的。建议进行多导睡眠监测以正确评估这些患者。
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