Leibowitz G, Shapiro M S, Salameh M, Glaser B
Department of Endocrinology and Metabolism, Hebrew University Hadassah Medical Centre, Jerusalem, Israel.
J Intern Med. 1994 Aug;236(2):231-5. doi: 10.1111/j.1365-2796.1994.tb01288.x.
Two acromegalic patients suffering from severe obstructive sleep apnoea syndrome were treated with the long-acting somatostatin analogue octreotide. Daytime sleepiness and fatigue improved within a few days. Repeat sleep studies performed after octreotide treatment revealed more confluent sleep with a shorter duration of sleep apnoea. Nocturnal hypoxaemia improved in one patient. Octreotide might be an effective noninvasive treatment for sleep apnoea of acromegaly.
