低剂量环磷酰胺与阿霉素加环磷酰胺治疗晚期卵巢癌的随机临床研究
Low-dose cyclophosphamide versus adriamycin plus cyclophosphamide in advanced ovarian cancer. A randomized clinical study.
作者信息
Bolis G, Bortolozzi G, Carinelli G, D'Incalci M, Gramellini F, Morasca L, Mangioni C
出版信息
Cancer Chemother Pharmacol. 1980;4(2):129-32. doi: 10.1007/BF00254034.
After intensive staging 74 ovarian cancer patients were randomized to two arms balanced for stage and post-surgery residual tumor. The two regimens were CTX 100 mg/day continuously and ADM 50 mg/m2 IV every 4 weeks plus CTX 100 mg/day. The response rates were respectively 42% and 52%. Median survival times were 13 and 14 months. The incidence of side effects was significantly higher in the combination-treatment arm. No other statistical differences were found.
经过强化分期后，74例卵巢癌患者被随机分为两组，两组在分期和术后残留肿瘤方面达到平衡。两种治疗方案分别为：持续每日静脉注射环磷酰胺（CTX）100mg；每4周静脉注射阿霉素（ADM）50mg/m²加每日静脉注射CTX 100mg。有效率分别为42%和52%。中位生存期分别为13个月和14个月。联合治疗组的副作用发生率显著更高。未发现其他统计学差异。
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