Viguera C, Ward J M, Nims R M, Wenk M L, Strandberg J D
J Am Vet Med Assoc. 1978 Nov 1;173(9):1198-201.
Two colonies of female outbred nude (athymic) mice were maintained by conventional standards of husbandry, but with special sanitary methods and segregation from other rodents. A total of 1,526 mice entered the colonies. Of these, 802 were untreated and most remained healthy. Necropsies were performed on 312 untreated mice that were sick and were killed or died naturally, and the tissues were examined microscopically. Clinical and pathologic conditions in the untreated mice included subcutaneous abscessation, dermatitis, subcutaneous edema due to glomerulonephritis (nephrotic syndrome), rectal prolapse, and lymphomas and other neoplasms.
两个雌性远交裸（无胸腺）小鼠群体按照常规饲养标准进行饲养，但采用了特殊的卫生方法，并与其他啮齿动物隔离。共有1526只小鼠进入这些群体。其中，802只未接受治疗，大多数保持健康。对312只生病后自然死亡或被处死的未治疗小鼠进行了尸检，并对组织进行了显微镜检查。未治疗小鼠的临床和病理状况包括皮下脓肿、皮炎、因肾小球肾炎（肾病综合征）导致的皮下水肿、直肠脱垂以及淋巴瘤和其他肿瘤。
