Schlag P, Veser J, Geier G, Breitig D, Herfarth C
Chir Forum Exp Klin Forsch. 1980:323-7.
Nucleic acid synthesis and influence of cytostatic agents (adriamycin, cyclophosphamide) were investigated in 73 cases of human breast cancer and in 19 cases of correlating lymph node metastases. An interrelationship between nucleic acid synthesis, proliferation and tumor stage could not be proven at the time of the operation. The labeling index, expressing the proliferation of tumor cells, and the incorporation of radiolabeled nucleic acid precursors (3H-thymidine, 3H-uridine) as an indicator of nucleic acid synthesis were higher in the investigated lymph node metastases than in the primary tumor. Nucleic acid synthesis was suppressed in primary and metastatic lesions in the same way by cytostatic agents.
在73例人类乳腺癌及19例相关淋巴结转移病例中，研究了细胞抑制剂（阿霉素、环磷酰胺）对核酸合成的影响。手术时未能证实核酸合成、增殖与肿瘤分期之间存在相互关系。作为肿瘤细胞增殖指标的标记指数，以及作为核酸合成指标的放射性标记核酸前体（3H-胸腺嘧啶核苷、3H-尿苷）的掺入，在研究的淋巴结转移中高于原发性肿瘤。细胞抑制剂以相同方式抑制原发性和转移性病变中的核酸合成。
