Bertermann O, Haussmann H
Chir Forum Exp Klin Forsch. 1980:329-32.
3 mg of 3,4 benzpyrene were injected subcutaneously into the neck of 90 male SD rats. After 140 days, fibrosarcomas developed in the same place. At a size of 2--4 g, the tumor was completely removed according to surgical rules. One group was operated only, whereas the other groups were subjected to operation and intraoperative or postoperative chemotherapy (CYVADIC). It could be shown that operation in combination with a postoperative chemotherapy significantly lengthens the survival period and reduces local recurrences, contrary to operation alone. Chemotherapy started intraoperatively does not increase the survival period. The considerable toxicity is an essential factor limiting the therapeutic process, although it reduces local recurrences. We think that the tumors of chemical genesis present a suitable model in addition to the graft tumors in testing new treatment forms against malignant diseases.
将3毫克的3,4-苯并芘皮下注射到90只雄性SD大鼠的颈部。140天后，在同一部位发生了纤维肉瘤。当肿瘤大小达到2-4克时，按照手术规则将其完全切除。一组仅接受手术，而其他组则接受手术并进行术中或术后化疗（CYVADIC方案）。结果表明，与单纯手术相比，手术联合术后化疗可显著延长生存期并减少局部复发。术中开始化疗并不能延长生存期。尽管化疗可减少局部复发，但其相当大的毒性是限制治疗进程的一个重要因素。我们认为，除了移植瘤外，化学诱导的肿瘤是测试针对恶性疾病的新治疗形式的合适模型。
