Shimomura Y, Kobayashi I, Maruto S, Ohshima K, Mori M, Kamio N, Fukuda H
Endocrinol Jpn. 1980 Feb;27(1):83-6. doi: 10.1507/endocrj1954.27.83.
A single oral dose (300 mg) of gamma-oryzanol extracted from rice-bran oil produced a significant reduction on the elevated serum TSH levels in hypothyroid patients. Similarly, chronic treatment with gamma-oryzanol resulted in decreased serum TSH levels in 6 of 8 patients. There was no change in the serum levels of thyroxine-iodine and triiodothyronine during the study. In addition, there was no difference in the serum TSH response to TRH in hypothyroid patients and normal subjects. These observations suggest that gamma-oryzanol inhibits serum TSH levels in patients with primary hypothyroidism, possibly by a direct action at the hypothalamus rather than the pituitary.
单次口服从米糠油中提取的γ-谷维素（300毫克）可使甲状腺功能减退患者升高的血清促甲状腺激素（TSH）水平显著降低。同样，γ-谷维素的长期治疗使8名患者中的6名血清TSH水平降低。在研究期间，血清甲状腺素碘和三碘甲状腺原氨酸水平没有变化。此外，甲状腺功能减退患者和正常受试者对促甲状腺激素释放激素（TRH）的血清TSH反应没有差异。这些观察结果表明，γ-谷维素可能通过在下丘脑而非垂体的直接作用来抑制原发性甲状腺功能减退患者的血清TSH水平。
