Ikehara Y, Mansho K, Kato K
J Biochem. 1978 Dec;84(6):1335-8. doi: 10.1093/oxfordjournals.jbchem.a132255.
A single injection of colchicine, 1 mg/kg body weight, remarkably increased the activity of alkaline phosphatase in rat livers, followed by its increase in serum. Combination of bile duct ligation with colchicine administration had an additional effect on the alkaline phosphatase level above those induced by the individual treatments alone. Treatment with cycloheximide significantly inhibited the inducible effect of colchicine on the enzyme suggesting that protein synthesis is prerequisite to the elevation of the alkaline phosphatase caused by colchicine treatment.
单次注射秋水仙碱（1毫克/千克体重）可显著提高大鼠肝脏中碱性磷酸酶的活性，随后血清中该酶的活性也会升高。胆管结扎与秋水仙碱给药相结合，对碱性磷酸酶水平的影响比单独进行这两种处理所诱导的影响更大。用放线菌酮处理可显著抑制秋水仙碱对该酶的诱导作用，这表明蛋白质合成是秋水仙碱处理导致碱性磷酸酶升高的前提条件。
