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[血管升压素和肾上腺肾上腺素在反射性冠状动脉血管收缩机制中的作用]

[Participation of vasopressin and adrenal gland adrenaline in the mechanism of reflex coronary vasoconstriction].

作者信息

Balueva T V, Borisova E A, Teplov S I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1980 Apr;66(4):549-54.

PMID:7389943
Abstract

In 17 acute experiments on sympatho- and vagotomized cats under chloralose anesthesia in conditions of stabilised blood pressure following bilateral common carotid arteries occlusion, similar coronaroconstriction occurred before and after adrenalectomy. The increase of latency and maximum of reaction were obvious in adrenalectomized cats as well as clear correlation between the coronaroconstriction and elective activation of HHNS as manifested in the increase of synthesis, transport, and release of vasopressin into blood flow. The data suggest participation of both endogenous vasopressin and epinephrine of adrenal glands in coronaroconstriction bollowing carotid occlusion.

摘要

在17项急性实验中,对氯醛糖麻醉下、双侧颈总动脉闭塞后血压稳定的交感神经和迷走神经切断的猫进行研究,肾上腺切除前后均出现了类似的冠状动脉收缩。在肾上腺切除的猫中,反应潜伏期和最大值的增加很明显,并且冠状动脉收缩与下丘脑-垂体-神经分泌系统(HHNS)的选择性激活之间存在明显相关性,表现为血管加压素合成、转运和释放到血流中的增加。数据表明,内源性血管加压素和肾上腺肾上腺素均参与了颈动脉闭塞后的冠状动脉收缩。

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