Angelkort B, Boateng K, Maurin N
J Int Med Res. 1980;8(3):242-6. doi: 10.1177/030006058000800310.
Blood fluidity depends on a number of factors of which especially the deformability of erythrocytes is of importance. Investigations reported in this paper have revealed an interdependence between blood fluidity and coagulability of blood. They confirm the significance of maintaining red cells deformability if an adequate microcirculation is to be provided in patients with occlusive vascular disease. High doses of oral pentoxifylline are able to improve erythrocyte flow rates in patients with occlusive vascular disorder. This agent also decreases platelet hyper-reactivity, a factor of importance in arresting the arteriosclerotic progression. In addition the hypercoagulability existing in such patients is reduced and the fibrinolytic system stimulated by treatment with the drug.
血液流动性取决于多种因素，其中红细胞的可变形性尤为重要。本文报道的研究揭示了血液流动性与血液凝固性之间的相互依存关系。这些研究证实，对于患有闭塞性血管疾病的患者，若要提供充足的微循环，维持红细胞的可变形性具有重要意义。高剂量口服己酮可可碱能够改善患有闭塞性血管疾病患者的红细胞流速。该药物还能降低血小板的高反应性，这是阻止动脉粥样硬化进展的一个重要因素。此外，此类患者存在的高凝状态会因该药物治疗而降低，且纤溶系统会受到刺激。
