Costa P P, Permutti B, Fernandes P, Croce G
Int J Clin Pharmacol Ther Toxicol. 1980;18(5):208-11.
Prazosine and isosorbide dinitrate have been studied in 15 patients with acute myocardial infarction complicated by heart failure. Prazosine at the first hour had a reduction of 39% of pulmonary capillary wedge pressure (PCWP), of 23% of systemic vascular resistences index (SVRI), of 20% of mean arterial pressure (AP). Isosorbide dinitrate at the first hour in a group of 7 patients had a decrease of SVRI by 19%, the cardiac index (CI) augmented by 23%, the PCWP fell by 15%, while in a group of 5 patients the drug had an increase of SVRI by 15%, a fall of 40% of PCWP and a slight decrease of CI.
对15例急性心肌梗死合并心力衰竭患者进行了哌唑嗪和硝酸异山梨酯的研究。在第1小时，哌唑嗪使肺毛细血管楔压（PCWP）降低39%，使体循环血管阻力指数（SVRI）降低23%，使平均动脉压（AP）降低20%。对于一组7例患者，硝酸异山梨酯在第1小时使SVRI降低19%，心脏指数（CI）增加23%，PCWP下降15%；而对于一组5例患者，该药物使SVRI增加15%，PCWP下降40%，CI略有下降。
