Nichols R L, Murray E S, Nisson P E
J Infect Dis. 1978 Dec;138(6):742-6. doi: 10.1093/infdis/138.6.742.
Guinea pigs in a test group were fed living guinea pig inclusion conjunctivitis (GPIC) organisms classified as Chlamydia psittaci in 60% yolk-sac suspensions as enteric vaccines, while animals in a control group received uninfected yolk sac. Seven test animals and 14 control animals were challenged 11 or 22 days later with 1,000 50% infectious doses of GPIC organisms in either the conjunctiva or the vagina. Evidence of protection from mucosal infection in both sites was noted in test animals. Clinically, the disease was less severe, and microbiologically, lower percentages of mucosal cells were infected. The results suggest that enteric vaccination against mucosal infections of the eye and the genital tract with chlamydial agents is possible.
试验组豚鼠喂食含活的豚鼠包涵体结膜炎（GPIC）病原体的肠道疫苗，这些病原体在60%卵黄囊悬液中被分类为鹦鹉热衣原体，而对照组动物接受未感染的卵黄囊。11天或22天后，7只试验动物和14只对照动物分别通过结膜或阴道接种1000个50%感染剂量的GPIC病原体进行攻毒。在试验动物中发现了对两个部位黏膜感染具有保护作用的证据。临床上，疾病症状较轻，微生物学检测显示，黏膜细胞感染率较低。结果表明，用衣原体制剂进行肠道疫苗接种以预防眼部和生殖道的黏膜感染是可行的。
