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药物试验:多剂量肌肉注射头孢孟多治疗尿路感染

Drug trials: treatment of urinary tract infection with multiple-dose intramuscular administration of cephamandole.

作者信息

Nankervis A, Fairley K F, Shaw P, Whitworth J A, Miles H, Graham I, Pavillard R

出版信息

Med J Aust. 1980 May 3;1(9):427-8.

PMID:7393095
Abstract

Therapy with cephamandole (1.0 g, every eight hours) for five days was effective in eliminating cephamandole-sensitive microorganisms from the urinary tract. A 75% cure rate was achieved in a group of 20 patients, 45% of whom had abnormalities of the urinary tract. Local pain (despite addition of lignocaine) was sufficiently prolonged and severe to make multiple-dose intramuscular administration unacceptable. No other toxic effects were encountered.

摘要

用头孢孟多(每8小时1.0克)治疗五天可有效清除尿路中的头孢孟多敏感微生物。在一组20名患者中治愈率达75%,其中45%的患者存在尿路异常。局部疼痛(尽管加用了利多卡因)持续时间足够长且程度严重,使得多剂量肌内注射难以接受。未发现其他毒性作用。

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