Aihara T, Miyata M, Ishikawa S
J Pediatr Ophthalmol Strabismus. 1978 Jan-Feb;15(1):43-7. doi: 10.3928/0191-3913-19780101-14.
The lactate dehydrogenase (LDH) isoenzyme pattern in normal eye muscles of fetuses, children, and adults in overacting inferior oblique muscles of children was studied and compared. No significant differences were found between LDH isoenzyme activity in the horizontal and vertical recti. Isoenzyme fractions, by percentage, were distributed in these muscles in the order of III greater than IV greater than II greater than V greater than I. A significant difference, however, was noted between the LDH isoenzyme patterns of the inferior oblique muscle in normal adults and children. The percentages were in the orders of III greater than II greater than IV greater than V greater than I, and III greater than IV greater than II greater than V greater than I, respectively. The isoenzyme pattern in the overacting inferior oblique muscles of children was in the order of III greather than II greater than IV greater than V greater than I, identical to that of the adult control group. In addition, the overacting inferior oblique muscle of the children contained more H than M subunit than did the rectus muscle or the normal inferior oblique muscle of children by comparison.
对胎儿、儿童和成人正常眼肌以及儿童下斜肌亢进患者的乳酸脱氢酶（LDH）同工酶模式进行了研究和比较。水平直肌和垂直直肌的LDH同工酶活性之间未发现显著差异。同工酶组分按百分比在这些肌肉中的分布顺序为Ⅲ＞Ⅳ＞Ⅱ＞Ⅴ＞Ⅰ。然而，正常成人和儿童下斜肌的LDH同工酶模式之间存在显著差异。其百分比顺序分别为Ⅲ＞Ⅱ＞Ⅳ＞Ⅴ＞Ⅰ和Ⅲ＞Ⅳ＞Ⅱ＞Ⅴ＞Ⅰ。儿童下斜肌亢进患者的同工酶模式顺序为Ⅲ＞Ⅱ＞Ⅳ＞Ⅴ＞Ⅰ，与成人对照组相同。此外，与儿童的直肌或正常下斜肌相比，儿童下斜肌亢进患者的下斜肌含有的H亚基比M亚基更多。
