免疫抑制预处理对艾氏腹水癌（EAC）攻击的小鼠存活的影响。
Influence of immunosuppressive pretreatment on the survival of mice challenged with Ehrlich ascites carcinoma (EAC).
作者信息
Jakóbisiak M, Lasek W, Kańtoch M, Rozmysłowicz T
出版信息
Neoplasma. 1980;27(2):147-50.
PMID:7393355
Abstract
Mice were pretreated with immunosuppressive doses of cyclophosphamide (CY), cortisone acetate (CA) or X-irradiation. 24 h later all mice were given 1 x 10(5) EAC cells intraperitoneally. In another experiment mice were splenectomized 1 h before injection of EAC cells. Neither CY nor CA pretreatment had significant influence on the survival of tumor-inoculated mice. On other hand, X-irradiation or splenectomy strengthened tumor resistance.
摘要
用免疫抑制剂量的环磷酰胺（CY）、醋酸可的松（CA）或X射线对小鼠进行预处理。24小时后，所有小鼠腹腔注射1×10⁵个艾氏腹水癌细胞（EAC细胞）。在另一项实验中，在注射EAC细胞前1小时将小鼠脾脏切除。CY和CA预处理对接种肿瘤小鼠的存活均无显著影响。另一方面，X射线照射或脾切除增强了肿瘤抵抗力。
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