Carry P J, Prescott D M, Ogilvie G K
Cancer Res. 1979 Jun;39(6 Pt 1):2139-40.
Ehrlich ascites tumor grows in almost any mouse host. We have found a strain of dystrophic mice to be strongly resistant to Ehrlich ascites tumor. Mice of the dystrophic strain survived injection of Ehrlich Ascites tumor cells that had just been passaged through either dystrophic mice or C57BL X DBA/2 F1, (hereafter known as BD2F1) mice. However, most of the dystrophic mice died when they were given injections of Ehrlich ascites tumor cells that had just been passaged through Swiss white mice. All Swiss white and BD2F1 mice died when they were inoculated with Ehrlich ascites tumor cells, regardless of the type of mouse through which the Ehrlich ascites tumor cells had just been passaged. In some dystrophic mice, the tumor grew to a palpabale size and then disappeared. This provided the opportunity to passage the tumor from one dystrophic mouse to another and thereby to demonstrate resistance in the dystrophic mice to tumor that had grown previously in dystrophic mice. There was no detectable difference in the rate of tumor growth in either Swiss white or BD2F1 mice.
艾氏腹水瘤几乎能在任何小鼠宿主体内生长。我们发现一种营养不良小鼠品系对艾氏腹水瘤具有很强的抗性。该营养不良品系的小鼠在注射刚通过营养不良小鼠或C57BL×DBA/2 F1（以下简称BD2F1）小鼠传代的艾氏腹水瘤细胞后存活下来。然而，当给大多数营养不良小鼠注射刚通过瑞士白化小鼠传代的艾氏腹水瘤细胞时，它们死亡了。所有瑞士白化小鼠和BD2F1小鼠在接种艾氏腹水瘤细胞后都会死亡，无论艾氏腹水瘤细胞刚通过何种类型的小鼠传代。在一些营养不良小鼠中，肿瘤长到可触及的大小后又消失了。这提供了将肿瘤从一只营养不良小鼠传给另一只的机会，从而证明营养不良小鼠对先前在营养不良小鼠体内生长的肿瘤具有抗性。瑞士白化小鼠或BD2F1小鼠的肿瘤生长速率没有可检测到的差异。
