Gas chromatography/high-resolution mass spectrometry as a reference method for clomipramine determination.

A method has been developed for the determination of plasma clomipramine levels, based on gas chromatography/high-resolution mass spectrometry. Accuracy and precision have been shown to be excellent in analyses of plasma samples to which known quantities of the drug have been added. In view of the great specificity achieved with high-resolution mass spectrometry, the technique is recommended for reference purposes. There is good agreement between results obtained by a routine radioimmunoassay and this reference method.