Seiler W O, Huser B, Marbet G, Mihatsch M J, Stähelin H B
Schweiz Med Wochenschr. 1980 May 3;110(18):685-9.
Healing of decubital ulcers is, in contrast to that in other skin wounds, protracted. The reason for this is still unknown. The microscopic findings show the typical picture of a chronic ulcer with prominent scar tissue. To investigate the fibrinolytic activity of the ulcer margin and the adjacent skin tissue, samples of 13 ulcers were obtained and incubated on fibrin plates using the technique of PERMIN, ASTRUP and MULLERTZ. Lytic activity is expressed as mm2 of the lysed fibrin spots. In the border zone (1.5 mm zone), fibrinolytic activity was significantly reduced (12.7 mm2) as compared with the activity of the 9 mm zone (38.1 mm2) of the adjacent skin. Skin samples at a distance of 12 mm from the ulcer border still exhibited significantly lower fibrinolytic activity (39.4 mm2) than normal skin (71.5 mm2). The significantly lower fibrinolytic activity of the ulcer border in decubital ulcers may contribute to the poor healing tendency and indicates a decreased microcirculation. The fibrinolytic activity test offers an objective test of therapeutic principles.
与其他皮肤伤口相比，褥疮溃疡的愈合过程较为漫长。其原因尚不清楚。显微镜检查结果显示出慢性溃疡伴有明显瘢痕组织的典型图像。为了研究溃疡边缘和相邻皮肤组织的纤溶活性，获取了13个溃疡的样本，并使用PERMIN、ASTRUP和MULLERTZ的技术在纤维蛋白平板上进行孵育。溶解活性以溶解的纤维蛋白斑点的平方毫米表示。在边缘区（1.5毫米区域），与相邻皮肤的9毫米区域（38.1平方毫米）的活性相比，纤溶活性显著降低（12.7平方毫米）。距离溃疡边缘12毫米处的皮肤样本的纤溶活性（39.4平方毫米）仍明显低于正常皮肤（71.5平方毫米）。褥疮溃疡边缘纤溶活性显著降低可能导致愈合倾向不佳，并表明微循环减少。纤溶活性测试为治疗原则提供了客观的测试方法。
