Burkart F
Schweiz Med Wochenschr. 1980 Jun 7;110(23):916-9.
Cardiac function is regulated by four parameters: heart rate, preload, contractility and after-load. In the treatment of heart failure cardiac function is influenced by way of these parameters. The longterm pacemaker can normalize heart rate in patients with bradycardia; diuretics and volume load influence the filling pressure of the heart, while glycosides and sympathomimetic drugs increase contractility. If these mechanisms fail, peripases cardiac work. Vasodilators reduce this peripheral constriction was well as the elevated preload, and can therefore improve cardiac performance. The use and limitations of these pharmacological agents are discussed.
心率、前负荷、收缩力和后负荷。在心力衰竭的治疗中，心脏功能通过这些参数受到影响。长期起搏器可使心动过缓患者的心率正常化；利尿剂和容量负荷影响心脏的充盈压力，而洋地黄和拟交感神经药物可增加收缩力。如果这些机制失效，心脏做功。血管扩张剂可减轻外周血管收缩以及升高的前负荷，因此可改善心脏功能。本文讨论了这些药物的使用及局限性。
