乙醇特异性增强猫大脑皮层中γ-氨基丁酸介导的神经传递。
Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex.
作者信息
Nestoros J N
出版信息
Science. 1980 Aug 8;209(4457):708-10. doi: 10.1126/science.7394531.
PMID:7394531
Abstract
Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by gamma-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibiton by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) gamma-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.
摘要
乙醇（酒精）增强γ-氨基丁酸对皮质神经元的抑制作用。这种作用具有特异性，因为乙醇不会增强甘氨酸、5-羟色胺或多巴胺的抑制作用。这些结果与酒精中毒相关，原因如下：（i）γ-氨基丁酸介导抗焦虑机制；（ii）焦虑与酒精中毒的病因有关。
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