吡咯里西啶生物碱（普通千里光）对肝脏混合功能氧化酶系统的影响。
The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.
作者信息
Eastman D F, Segall H J
出版信息
Toxicol Lett. 1980 May;5(6):369-74. doi: 10.1016/0378-4274(80)90017-x.
PMID:7394831
Abstract
A model system to detect the toxicity of pyrrolizidine alkaloids (PAs) was explored. Using the liver S-10 fraction, the effect of PAs on aniline hydroxylase and aminopyrine N-demethylase was examined. PAs were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.
摘要
探索了一种检测吡咯里西啶生物碱（PAs）毒性的模型系统。利用肝脏S-10组分，研究了PAs对苯胺羟化酶和氨基比林N-脱甲基酶的影响。PAs对氨基比林N-脱甲基酶酶系统有毒性，而对苯胺羟化酶酶系统无毒性。
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