6-氨基 Chrysene 对肝微粒体酶活性的影响。
Effects of 6-aminochrysene on liver microsomal enzyme activity.
作者信息
Russo R, Bartosek I, Villa S, Guaitani A, Garattini S
出版信息
Xenobiotica. 1976 Apr;6(4):201-5. doi: 10.3109/00498257609151630.
PMID:936641
Abstract
- No transformation of 6-aminochrysene took place during its incubation with rat liver microsomes under oxygen or anaerobic conditions. 2. 6-Aminochrysene inhibited the hydroxylation of aniline, O-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. 3. Pre-treatment of rats with 6-aminochrysene markedly decreased the N-demethylation in vitro but significantly increased the hydroxylation and the O-demethylation. Similar effects were observed also with microsomal preparations from livers perfused with 6-aminochrysene.
摘要
- 在有氧或无氧条件下，6-氨基 Chrysene 与大鼠肝微粒体温育时未发生转化。2. 6-氨基 Chrysene 抑制大鼠肝微粒体对苯胺的羟基化作用、对硝基苯甲醚的 O-去甲基化作用以及氨基比林的 N-去甲基化作用。3. 用 6-氨基 Chrysene 预处理大鼠显著降低了体外 N-去甲基化作用，但显著增加了羟基化作用和 O-去甲基化作用。在用 6-氨基 Chrysene 灌注肝脏的微粒体制剂中也观察到了类似的效果。
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