Hillman P E, Scott N R, van Tienhoven A
Am J Physiol. 1980 Jul;239(1):R57-61. doi: 10.1152/ajpregu.1980.239.1.R57.
Intraventricular injections of 5-hydroxytryptamine-HCl (258 nmol) or acetylcholine-HCl (550 nmol) in the chicken caused body temperature to rise at 35 degrees C ambient, a result of decreased evaporative heat loss due to bradypnea. At 10 and 20 degrees C ambient, neither drug affected body temperature. Although these drugs decreased physical activity or shivering or both at 10 and 20 degrees C, metabolic heat production was not depressed enough to alter body temperature significantly. Heart rate decreased simultaneously with decreased activity at 20 degrees C. This study is the first to inject 5-hydroxytryptamine as a salt of HCl, instead of creatinine sulfate, as is commonly used. It is suggested that some of the differences reported herein, compared to other studies, are due to the type of salt used. It is postulated that either 5-hydroxytryptamine or acetylcholine, rather than norepinephrine, may be an important neurotransmitter in the neural pathways for thermoregulation in chickens, even though their action on thermoregulation is minor compared with norepinephrine.
在鸡的脑室内注射盐酸5-羟色胺（258纳摩尔）或盐酸乙酰胆碱（550纳摩尔），在35摄氏度的环境温度下会导致体温升高，这是由于呼吸缓慢导致蒸发散热减少的结果。在10摄氏度和20摄氏度的环境温度下，这两种药物均不影响体温。尽管这些药物在10摄氏度和20摄氏度时会降低身体活动或颤抖或两者皆有，但代谢产热并未降低到足以显著改变体温的程度。在20摄氏度时，心率随着活动的减少而同时降低。本研究首次将盐酸盐形式的5-羟色胺而非常用的硫酸肌氨酸盐进行注射。与其他研究相比，本文报道的一些差异可能是由于所使用的盐的类型所致。据推测，5-羟色胺或乙酰胆碱而非去甲肾上腺素可能是鸡体温调节神经通路中的重要神经递质，尽管它们对体温调节的作用与去甲肾上腺素相比很小。
