Alvarez L, De Miguel E, Calvet E, Ramón F
An Esp Pediatr. 1980 Feb;13(2):133-50.
Authors studied L.D.H .and Isoenzymes of L.D.H. activities in 254 C.S.F. corresponding to 112 children affected with different diseases. The purpose was to discover its diagnostic utility and possible etiological explanation. Results have been compared with reference values found in a previous study. Highest enzymatic activities of L.D.H. are observed, in decreasing order, in tumours, terminal process, endocranial hipertension plus meningitis, and meningitis. Referring to different types of meningitis, highest enzymatic activity of L.D.H. was found in bacterial type, especially those caused by a germen different from "Neisseria meningitidis". An inversion of isoenzymatic pattern is observed with an increase of L.D.H.-4 and L.D.H.-5 in detriment of L.D.S.-1 and L.D.S.-2, in tumours, endocranial hipertension plus meningitis and in all infections of central nervous system in the initial phase, returning to normal in recuperation phase of disease. A possible enzymatic etiology in different pathological diseases is suggested. In conclusion, it is of interest to determine L.D.H. and its isoenzymes as control of disease but not as differential diagnosis.
作者研究了254份与112名患有不同疾病儿童相对应的脑脊液中的乳酸脱氢酶（L.D.H.）及其同工酶活性。目的是发现其诊断效用及可能的病因解释。研究结果已与先前研究中发现的参考值进行了比较。乳酸脱氢酶的最高酶活性按降序排列见于肿瘤、终末期、颅内高压合并脑膜炎以及脑膜炎。就不同类型的脑膜炎而言，乳酸脱氢酶的最高酶活性见于细菌性脑膜炎，尤其是由不同于“脑膜炎奈瑟菌”的病菌引起的细菌性脑膜炎。在肿瘤、颅内高压合并脑膜炎以及中枢神经系统所有感染的初始阶段，观察到同工酶模式发生倒置，即乳酸脱氢酶-4（L.D.H.-4）和乳酸脱氢酶-5（L.D.H.-5）增加，而乳酸脱氢酶-1（L.D.S.-1）和乳酸脱氢酶-2（L.D.S.-2）减少，在疾病恢复阶段恢复正常。文中提出了不同病理疾病中可能的酶学病因。总之，测定乳酸脱氢酶及其同工酶有助于疾病的监测，但无助于鉴别诊断。
